Global

For a spiky sphere just 120 nanometers wide, the coronavirus can be a remarkably cosmopolitan traveler.

Spewed from the nose or mouth, it can rocket across a room and splatter onto surfaces; it can waft into poorly ventilated spaces and linger in the air for hours. At its most intrepid, the virus can spread from a single individual to dozens of others, perhaps even a hundred or more at once, proliferating through packed crowds in what is called a superspreading event.

For months, the call for coronavirus testing has been led by one resounding refrain: To keep outbreaks under control, doctors and researchers need to deploy the most accurate tests available — ones reliable enough to root out as many infections as possible, even in the absence of symptoms.

That’s long been the dogma of infectious disease diagnostics, experts say, since it helps ensure that cases won’t be missed. During this pandemic, that has meant relying heavily on PCR testing, an extremely accurate but time- and labor-intensive method that requires samples to be processed at laboratories.

It begins with a mild fever and malaise, followed by a painful cough and shortness of breath. The infection prospers in crowds, spreading to people in close reach. Containing an outbreak requires contact tracing, as well as isolation and treatment of the sick for weeks or months.

This insidious disease has touched every part of the globe. It is tuberculosis, the biggest infectious-disease killer worldwide, claiming 1.5 million lives each year.